|
KMID : 0043320070300040408
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 4 p.408 ~ p.411
|
|
|
A New Cytotoxic Prenylated Chalcone from Sophora flavescens
|
|
Lee Jae-Hyeok
Baek Nam-In
Kim Sung-Hoon
Park Hee-Wook
Yang Jae-Heon
Lee Jeong-Joo
Kim Seong-Jin
Jeong Seung-Il
Oh Chan-Ho
Lee Gyu-Hee
Kim Dae-Keun
|
|
|
Abstract
|
|
|
|
We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2’,4’-tetrahydroxy-8-isopentenyl-5- methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.
|
|
|
KEYWORD
|
|
|
Sophora flavescens, Leguminosae, Prenylated chalcone, 7, 9, 2’, 4’-Tetrahydroxy-8-isopentenyl-5-methoxychalcone, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|